Synthesis of 3-fluoro azetidinone by ele
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Jean-Pierre GenΓͺt; Jean-Olivier Durand; Sylvain Roland; Monique Savignac; FrΓ©dΓ©r
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Article
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1997
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Elsevier Science
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French
β 200 KB
An easy access to the 3-fluoroazetidinone 4a based on electrophilic fluorination, is reported. The fluorination of the ~l-lactam 7 with Differding's N-fluorosulfonimide proceeds stereoselectively, under mild conditions and in good yield.