Synthesis of Fluorinated Ketoheptoses as Specific Diagnostic Agents
β Scribed by Daniel Waschke; Yevgeniy Leshch; Julian Thimm; Uwe Himmelreich; Joachim Thiem
- Book ID
- 102829122
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 837 KB
- Volume
- 2012
- Category
- Article
- ISSN
- 1434-193X
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π SIMILAR VOLUMES
## Abstract Tolbutamide (**1**) and glyburide (**7**) are hypoglycemic drugs used to stimulate insulin secretion in type **2** diabetic patients. We have synthesized their fluorineβ18 labeled analogs, 1β[(4β[^18^F]fluorobenzenesulfonyl)]β3βbutyl]urea (__p__β[^18^F]fluorotolbutamide, **3a**) and Nβ{
One pot synthesis of fluorinated 4H-1,4-benzothiazines can be effected by the condensation and oxidative cyclization of substituted 2-aminobenzenethiols with B-diketone (pfluorobenzoylacetone) in DMSO. The reaction is believed to proceed via an enamino-ketone system. The structures have been confirm