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Single step synthesis of Fluorinated 4H-1,4-Benzothiazines as possible anticancer agents

✍ Scribed by Dr. Vandana Gupta; Dr. R. R. Gupta


Book ID
105353842
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
166 KB
Volume
333
Category
Article
ISSN
1615-4150

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One pot synthesis of fluorinated 4H-1,4-benzothiazines can be effected by the condensation and oxidative cyclization of substituted 2-aminobenzenethiols with B-diketone (pfluorobenzoylacetone) in DMSO. The reaction is believed to proceed via an enamino-ketone system. The structures have been confirm

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## Abstract New compounds of 2‐aryl‐4__H__‐3,1‐benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl‐modified sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with 2