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Synthesis and Anticancer Activity of New 2-Aryl-4H-3,1-benzothiazines

✍ Scribed by Andrzej Niewiadomy; Joanna Matysiak; Monika M. Karpińska

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
153 KB
Volume
344
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

New compounds of 2‐aryl‐4__H__‐3,1‐benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl‐modified sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with 2‐aminobenzyl alcohols. The reaction proceeded through thiobenzanilide intermediates, which were converted to the 4__H__‐3,1‐benzothiazine fused ring by an endocyclization process. The structures of compounds were identified from elemental, IR, ^1^H‐NMR, ^13^C‐NMR, and MS spectra analyses. The cytotoxicity in vitro against four human cancer cell lines was determined. The antiproliferative properties of some compounds were more beneficial than cisplatin studied comparatively.

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