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One-pot synthesis of new fluorinated 4H-1,4-benzothiazines as possible anticancer agents

✍ Scribed by R.R. Gupta; A. Thomas; R.K. Gautam; V. Gupta

Book ID
104150880
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
446 KB
Volume
44
Category
Article
ISSN
0022-1139

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✦ Synopsis

One pot synthesis of fluorinated 4H-1,4-benzothiazines can be effected by the condensation and oxidative cyclization of substituted 2-aminobenzenethiols with B-diketone (pfluorobenzoylacetone) in DMSO. The reaction is believed to proceed via an enamino-ketone system. The structures have been confirmed by their elemental analyses and spectral studies. p-Fluorobenzoylacetone has been synthesized by Claisen condensation of ethyl acetate with p-fluoroacetophenone.

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Synthesis and Anticancer Activity of New
Synthesis and Anticancer Activity of New 2-Aryl-4H-3,1-benzothiazines
✍ Andrzej Niewiadomy; Joanna Matysiak; Monika M. KarpiΕ„ska πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 153 KB πŸ‘ 2 views

## Abstract New compounds of 2‐aryl‐4__H__‐3,1‐benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl‐modified sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with 2