Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase
✍ Scribed by José-Luis Giner; Karen A Kehbein; James A. Cook; Michele C. Smith; Chris J. Vlahos; John A. Badwey
- Book ID
- 108073948
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 214 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0960-894X
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title esters, e.g. (Ib)-(Ie), are synthesized by deacetylation and subsequent reacylation of wortmannin (Ia). In comparison with the latter one, they show superior inhibition of phosphatidylinositol (PI) 3-kinase and increased cell cytotoxicity in vitro. Reduction of (Ib) to (IIa) slightly enhances
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