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A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase

โœ Scribed by Ruediger Woscholski; Tsutomu Kodaki; Murray McKinnon; Michael D. Waterfield; Peter J. Parker


Book ID
115930268
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
899 KB
Volume
342
Category
Article
ISSN
0014-5793

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ChemInform Abstract: Synthesis and in vi
โœ L. C. CREEMER; H. A. KIRST; C. J. VLAHOS; R. M. SCHULTZ ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

title esters, e.g. (Ib)-(Ie), are synthesized by deacetylation and subsequent reacylation of wortmannin (Ia). In comparison with the latter one, they show superior inhibition of phosphatidylinositol (PI) 3-kinase and increased cell cytotoxicity in vitro. Reduction of (Ib) to (IIa) slightly enhances