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Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase

โœ Scribed by Creemer, Lawrence C.; Kirst, Herbert A.; Vlahos, Chris J.; Schultz, Richard M.


Book ID
127371593
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
166 KB
Volume
39
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Synthesis and in vi
โœ L. C. CREEMER; H. A. KIRST; C. J. VLAHOS; R. M. SCHULTZ ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

title esters, e.g. (Ib)-(Ie), are synthesized by deacetylation and subsequent reacylation of wortmannin (Ia). In comparison with the latter one, they show superior inhibition of phosphatidylinositol (PI) 3-kinase and increased cell cytotoxicity in vitro. Reduction of (Ib) to (IIa) slightly enhances