ChemInform Abstract: Synthesis and in vi
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L. C. CREEMER; H. A. KIRST; C. J. VLAHOS; R. M. SCHULTZ
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Article
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2010
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John Wiley and Sons
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title esters, e.g. (Ib)-(Ie), are synthesized by deacetylation and subsequent reacylation of wortmannin (Ia). In comparison with the latter one, they show superior inhibition of phosphatidylinositol (PI) 3-kinase and increased cell cytotoxicity in vitro. Reduction of (Ib) to (IIa) slightly enhances