Synthesis of fluorescent adenosine derivatives

✍ Scribed by K.F. Yip; K.C. Tsou

• Book ID: 104247258
• Publisher: Elsevier Science
• Year: 1973
• Tongue: French
• Weight: 159 KB
• Volume: 14
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)96326-9

✦ Synopsis

When l,N6-etheno-adenosine, 1, was treated with sodium hydroxide, it lost fluorescence and gave 3-g-D-ribofuranosyl-4-amino-5-(imidazol-2-y1) imidazole 6. Nitrosation of 6' yielded 2-asa-l,N6-etheno-adenoaine, 11 (Scheme I).

Toxicity studies showed that 11 is selectively active in rat maPmnary tumor (AC-33)tissue culture system, although.inactive in other tissue culture, (e.g., HeLa and Glioma 26).I

In order to obtain further information concerning the unique properties of the 2-aza-l,N6etheno-adenosine in the biological system , the synthesis of other related 2-aza-l,N'-ethenoadenosine derivatives was undertaken. Because of the unique fluorescent properties and the importance of the c-adenosine 2,3 in biochemical studies. we wish to describe the