Fluorescent glucagon derivatives. I. Synthesis and characterisation of fluorescent glucagon derivatives
β Scribed by Helmuth Heithier; Larry D. Ward; Richard C. Cantrill; Helmut W. Klein; Mi-Jae Im; Gabriele Pollak; Barbara Freeman; Emile Schiltz; Reiner Peters; Ernst J.M. Helmreich
- Book ID
- 117046856
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 687 KB
- Volume
- 971
- Category
- Article
- ISSN
- 0005-2728
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When l,N6-etheno-adenosine, 1, was treated with sodium hydroxide, it lost fluorescence and gave 3-g-D-ribofuranosyl-4-amino-5-(imidazol-2-y1) imidazole 6. Nitrosation of 6' yielded 2-asa-l,N6-etheno-adenoaine, 11 (Scheme I). Toxicity studies showed that 11 is selectively active in rat maPmnary tumo
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