Synthesis of fluorescent adenosine deriv
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K.F. Yip; K.C. Tsou
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Article
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1973
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Elsevier Science
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French
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When l,N6-etheno-adenosine, 1, was treated with sodium hydroxide, it lost fluorescence and gave 3-g-D-ribofuranosyl-4-amino-5-(imidazol-2-y1) imidazole 6. Nitrosation of 6' yielded 2-asa-l,N6-etheno-adenoaine, 11 (Scheme I). Toxicity studies showed that 11 is selectively active in rat maPmnary tumo