Synthesis of flexibilene, a naturally occurrring 15-membered-ring diterpene
β Scribed by John McMurry; James R. Matz; Kenneth L. Kees; Peter A. Bock
- Book ID
- 104220244
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 194 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The intramolecular SNAr reaction of a linear peptid precursor, whose termini carry respectively an ortho fluoro-nitro group and a phenol function, gives the 15membered ring compound in good yield, under mild conditions.
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A 16+15 membered bicyclic polypeptide containing biaryl ether bonds, model of A-O-C-B-O-D rings of kistamicin has been synthesized by sequential intramolecular SNAr reactions.