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The first synthesis of a 15-membered macrocycle. Model of ring I of kistamycin

✍ Scribed by Georges Roussi; Eduardo González Zamora; Annie-Claude Carbonnelle; René Beugelmans

Book ID
104257300
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
115 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The intramolecular SNAr reaction of a linear peptid precursor, whose termini carry respectively an ortho fluoro-nitro group and a phenol function, gives the 15membered ring compound in good yield, under mild conditions.

📜 SIMILAR VOLUMES

The first synthesis of simplified 16- an
The first synthesis of simplified 16- and 17-membered ring macropolypeptides containing the phenyl-indole system of kistamycin and chloropeptin I, II
✍ Annie-Claude Carbonnelle; Eduardo González Zamora; René Beugelmans; Georges Rous 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 125 KB

The .rynthesis of simplified 16-and 17-membered rin~ macropolvpeptides was achieved hv Ni ~ mediated carbon-carbon ring closure of properly substituted linear precursors.