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Synthesis of [F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC): a PET tracer for tumor delineation

✍ Scribed by Timothy M. Shoup; Mark M. Goodman


Book ID
101284010
Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
443 KB
Volume
42
Category
Article
ISSN
0022-2135

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## Abstract A fluorine‐18 labeled analog of the widely used chemotherapeutic agent cyclophosphamide was synthesized as a tracer for prognostic imaging with positron emission tomography. 2‐[(2‐Chloro‐2′‐[^18^F]fluoroethyl)amino]‐2H‐1,3,2‐oxazaphosphorinane‐2‐oxide (^18^F‐fluorocyclophosphamide), was