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Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides

✍ Scribed by Ren, Qin; Tsunaba, Kana; Kitamura, Yoshiaki; Nakashima, Remi; Shibada, Aya; Ikeda, Masato; Kitade, Yukio


Book ID
121716141
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
487 KB
Volume
24
Category
Article
ISSN
0960-894X

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## Abstract The synthesis of 4(5)‐(bromomethyl)fluorescein, which can be used as its 3β€²,6′‐dibenzoyl derivative 7 for the labelling of nucleosides is described. Pyrimidine nucleosides such as 3′‐and/or5′‐protected 2′‐deoxyuridine and thymidine are labelled by 7 at N^3^ of the heterocyclic base. The