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A Fluorescent Radioiodinated Oligonucleotidic Photoaffinity Probe for Protein Labeling: Synthesis and Photolabeling of Thrombin

✍ Scribed by Berens, Catherine; Courtoy, Pierre J.; Sonveaux, Etienne


Book ID
125961160
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
127 KB
Volume
10
Category
Article
ISSN
1043-1802

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## Abstract The synthesis of 4(5)‐(bromomethyl)fluorescein, which can be used as its 3β€²,6′‐dibenzoyl derivative 7 for the labelling of nucleosides is described. Pyrimidine nucleosides such as 3′‐and/or5′‐protected 2′‐deoxyuridine and thymidine are labelled by 7 at N^3^ of the heterocyclic base. The