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Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression

✍ Scribed by Erik F.J de Vries; Joke Vroegh; Gerard Dijkstra; Han Moshage; Philip H Elsinga; Peter L.M Jansen; Willem Vaalburg

Book ID
116798764
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
242 KB
Volume
31
Category
Article
ISSN
0969-8051

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## Abstract Uncharged derivatives of thioflavin‐T have known __in vitro__ and __in vivo__ affinity for amyloid Ξ². We synthesized and evaluated two derivatives with a fluorine‐18 labelled fluoropropoxy substituent either at the 6‐position or at the 2′‐position of the 2‐(4′‐aminophenyl)‐1,3‐benzothia