𝔖 Bobbio Scriptorium
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Synthesis of (−)-Epibatidine

✍ Scribed by Evans, David A.; Scheidt, Karl A.; Downey, C. Wade


Book ID
121363825
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
146 KB
Volume
3
Category
Article
ISSN
1523-7060

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Synthesis of epibatidine
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A total synthesis of racemic epibatidine, a natural product with analgesic activity, is described. Distinctly different from the previously published routes it starts from simple, known alkaloid in six steps.

Total synthesis of (±)-epibatidine
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✍ Nilantha S. Sirisoma; Carl R. Johnson 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 191 KB

A synthesis of the non-opiate analgesic alkaloid epibatidine was achieved in 13 steps and 13% overall yield starting from 1,3-cyclohexadiene using in a key step a modified Stille coupling reaction on an c~-iodocyclohexenone.