Synthesis of enantiomers of exo-2-norbornyl-N-n-butylcarbamate and endo-2-norbornyl-N-n-butylcarbamate for stereoselective inhibition of acetylcholinesterase
✍ Scribed by Shyh-Ying Chiou; Chuan-Fu Huang; Shyh-Jei Yeh; I-Ru Chen; Gialih Lin
- Book ID
- 102073587
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 313 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0899-0042
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## Abstract Carbamates are used to treat Alzheimer's disease. These compounds inhibit acetylcholinesterase and butyrylcholinesterase. The goal of this work is to use the substrate analogs of butyrylcholinesterase, 3,3‐dimethylbutyl‐__N__‐__n__‐butylcarbamate (1) and 2‐trimethylsilyl‐ethyl‐__N__‐__n
## Abstract Enantiomers of __cis__,__cis__‐decahydro‐2‐naphthyl‐N‐__n__‐butylcarbamate show stereo‐specific inhibition for acetylcholinesterase and butyrylcholinesterase. For both inhibition reaction, (2__S__,4a__R__,8a__S__)‐__cis__,__cis__‐decahydro‐2‐naphthyl‐N‐__n__‐ butylcarbamate is more pote