The conversion of myo-inositol into the ammonium salts both of racemic and enantiomerically pure I&myo-inositol 1,4,5\_trisphosphate ( 6) is described. The n.m.r. spectroscopic properties and biological activity of synthetic and naturally-isolated (6) are virtually identical.
Synthesis of enantiomerically pure D-myo-inositol 1,5,6-triphosphate
✍ Scribed by Grzegorz M. Salamończyk; K.Michał Pietrusiewicz
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 161 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The. synthesis of enantiomerically pure Dq&nositol 1.5.~bisphosphate fkom myoinositol involving two sequential rcgiosdective pmtections of hydroxyl groups in the intcmwdiate selfresolving rnp-inositol camphor monoacetal has been accomplished Recent investigations of the phosphoinositide signal transduction systems have revealed that enormous number of inositol phosphates and related phospholipids are present in eukaryotic cells.1 The chemical
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