An effective synthesis of IJ-w-inositol 1,4,5\_triphosphate was developed using a chiral inositide precursor which can be prepared via a facile enzymatic or chemical method. Recently, much attention has been focused on the metabolic cascade of membrane phosphoinositides, which regulates intracellula
Synthesis of D-myo-inositol 1,4,5-triphosphate
β Scribed by Colin B Reese; John G Ward
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 270 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
The conversion of myo-inositol into the ammonium salts both of racemic and enantiomerically pure I&myo-inositol 1,4,5_trisphosphate ( 6) is described.
The n.m.r. spectroscopic properties and biological activity of synthetic and naturally-isolated (6) are virtually identical.
π SIMILAR VOLUMES
The. synthesis of enantiomerically pure Dq&nositol 1.5.~bisphosphate fkom myoinositol involving two sequential rcgiosdective pmtections of hydroxyl groups in the intcmwdiate selfresolving rnp-inositol camphor monoacetal has been accomplished Recent investigations of the phosphoinositide signal trans