An efficient synthesis of optically active D-myo-inositol 1,4,5-triphosphate

✍ Scribed by Yeuk-Chuen Liu; Ching-Shih Chen

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 261 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)99535-2

✦ Synopsis

An effective synthesis of IJ-w-inositol 1,4,5_triphosphate was developed using a chiral inositide precursor which can be prepared via a facile enzymatic or chemical method. Recently, much attention has been focused on the metabolic cascade of membrane phosphoinositides, which regulates intracellular Ca +2 mobilization in response to a variety of extracellular signalsl. This complex information-transducing process is initiated by a receptor-mediated breakdown of phosphatidyl inositol 4,5-bisphosphate with the formation of Q-z-inositol 1,4,5-triphosphate [Ins(1,4,5)P3] (A) and 1,2-diacylglycerol, both of which function as second messengers eliciting specific intracellular responses.