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Synthesis of elemane bis-lactones structurally related to vernolepin

✍ Scribed by Gonzalo Blay; Luz Cardona; Begoña García; Luisa Lahoz; JoséR Pedro

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
191 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The chemical transformation of santonin into an elemane bis-lactone structurally related to the antitumour compound vemolepin is reported. The transformation of ring A of santonin into a hemiacetal ~-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obtained in this way revealed that the proposed structure for the natural product should be revised.

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