𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and synthesis of macro-heterocycles structurally related to tirofiban

✍ Scribed by Mahesh Ramaseshan; Martin Robitaille; John W Ellingboe; Yves L Dory; Pierre Deslongchamps *

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
231 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18-or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence.

📜 SIMILAR VOLUMES

Synthesis of three new compounds structu
Synthesis of three new compounds structurally related to damascone and ionone
✍ Jan G. Witteveen; Anton J. A. van der Weerdt 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 435 KB

## Abstract 1‐(3,6,6‐Trimethyl‐1,3‐cyclohexadien‐1‐yl)‐2‐buten‐1‐one (**1**), a β‐damascenone isomer, was synthesized from 3,6,6‐trimethyl‐2‐cyclohexenone (**14**). This starting ketone **14** was obtained in good yield from 3‐methyl‐2‐butanone (**11**) and 3‐buten‐2‐one (**12**). Ethynylation of *

Design, synthesis, and anti- Trypanosoma
Design, synthesis, and anti- Trypanosoma cruzi evaluation of a new class of cell-growth inhibitors structurally related to Fenoxycarb
✍ Andrea J. Schvartzapel; Laura Fichera; Mónica Esteva; Juan B. Rodriguez; Eduardo 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 German ⚖ 563 KB

Several compounds, structurally related to the insect-growth regulator Fenvxycarb (l), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanmvma cruzi cells (epimastigotes). Compounds 6,16, 18, and 22 were very active against 7'. cruzi making them promising good c