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Synthesis and pharmacological investigation of cholinergic ligands structurally related to muscarone

โœ Scribed by Marco De Amici; Carlo De Micheli; Enzo Grana; Roberto Rodi; Franco Zonta; Maria Grazia Santagostino-Barbone


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
731 KB
Volume
24
Category
Article
ISSN
0223-5234

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Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18-or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate