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Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics

✍ Scribed by M.F. Semmelhack; Christina Bodurow; Mary Baum


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
286 KB
Volume
25
Category
Article
ISSN
0040-4039

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Synthesis of elemane bis-lactones struct
✍ Gonzalo Blay; Luz Cardona; BegoΓ±a GarcΓ­a; Luisa Lahoz; JosΓ©R Pedro πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 191 KB

The chemical transformation of santonin into an elemane bis-lactone structurally related to the antitumour compound vemolepin is reported. The transformation of ring A of santonin into a hemiacetal ~-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obt