Synthesis of elemane bis-lactones struct
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Gonzalo Blay; Luz Cardona; BegoΓ±a GarcΓa; Luisa Lahoz; JosΓ©R Pedro
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Article
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1998
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Elsevier Science
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French
β 191 KB
The chemical transformation of santonin into an elemane bis-lactone structurally related to the antitumour compound vemolepin is reported. The transformation of ring A of santonin into a hemiacetal ~-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obt