Synthesis of Isotopically Labeled (E)-β,
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José M. Concellón; Pablo L. Bernad; Humberto Rodríguez-Solla
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Article
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2001
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John Wiley and Sons
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English
⚖ 73 KB
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A simple, efficient, highly diastereoselective method for preparing (E)-α,δ-dideuterio-β,γ-unsaturated esters: SmI -promoted reduction/elimination of α-halo-β-hydroxy-γ,δ-unsaturated esters in the presence of D O. This provides the desired products in which the C-C double bond is generated with tota