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Synthesis of (E)-α,β-Unsaturated Ketones with Total or High Diastereoselectivity by sing Samarium Diiodide or Triiodide.

✍ Scribed by Jose M. Concellon; Monica Huerta


Publisher
John Wiley and Sons
Year
2003
Weight
117 KB
Volume
34
Category
Article
ISSN
0931-7597

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✍ José M. Concellón; Pablo L. Bernad; Humberto Rodríguez-Solla 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB 👁 1 views

A simple, efficient, highly diastereoselective method for preparing (E)-α,δ-dideuterio-β,γ-unsaturated esters: SmI -promoted reduction/elimination of α-halo-β-hydroxy-γ,δ-unsaturated esters in the presence of D O. This provides the desired products in which the C-C double bond is generated with tota