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Synthesis of (E)-α,β-Unsaturated Esters and (Z)-Vinyl Halides with Total or High Diastereoselectivity by Using Samarium Metal

✍ Scribed by José M. Concellón; Humberto Rodríguez-Solla; Mónica Huerta; Juan A. Pérez-Andrés


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
144 KB
Volume
2002
Category
Article
ISSN
1434-193X

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Synthesis of Isotopically Labeled (E)-β,
✍ José M. Concellón; Pablo L. Bernad; Humberto Rodríguez-Solla 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB

A simple, efficient, highly diastereoselective method for preparing (E)-α,δ-dideuterio-β,γ-unsaturated esters: SmI -promoted reduction/elimination of α-halo-β-hydroxy-γ,δ-unsaturated esters in the presence of D O. This provides the desired products in which the C-C double bond is generated with tota