Synthesis of (E)-α,β-Unsaturated Amides
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José M. Concellón; Juan A. Pérez-Andrés; Humberto Rodríguez-Solla
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Article
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2001
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John Wiley and Sons
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English
⚖ 129 KB
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Stereoselective b-elimination of 2-chloro-3-hydroxyamides 1 is achieved by using samarium diiodide to yield a,b-unsaturated amides 2, in which the C C bond is di-tri-, or tetrasubstituted. The starting compounds 1 are easily prepared by reaction of the corresponding lithium enolates of a-chloroamide