Synthesis of dl-glutamine-2,5-15N2
β Scribed by William M. Lagna; Patrick S. Callery
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 258 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
A synthesis of the title compound from /13Clparaformaldehyde and [15N)ammonium chloride V f 8 ethyl 2-(1 ,3-/2-13Cldithianyl) acetate 3a is described. Ethyl/3-13C13-oxopropanoate derived in sl'tu from 3a was converted by a stepwise Strecker procedure to DL-[ 2-13C,15Nlaspartic acid 7a.
## Abstract The title compounds have been prepared by a simple and economical procedure from the corresponding Bocprotected Ξ±βbenzyl esters and [^15^N]ammonia with N,Nβ²βcarbonyldiimidazole as coupling agent. Catalytic hydrogenolysis furnished both labelled products in high overall yields suitable f
## Abstract [3β^13^C]βEthyl farnesoate was prepared by alkylating 3β^13^Cβethyl acetoacetate with geranyl bromide, followed by hydrolysis, decarboxylation and treatment with the anion of triethyl phosphonoacetate. The ester was reduced with LAH, brominated with CBr~4~/Ο~3~P, and the farnesyl bromid