Synthesis of d,l-1-13C-methionine
✍ Scribed by B. D. Andresen
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 239 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The stable, isotopically labelled amino acid d, 1‐1^13^C‐methionine, was prepared synthetically from 90% K^13^CN and 3‐(methylthio‐propionaldehyde. Chromatographic, infrared and mass spectrometric properties are presented which aid in the identification of this compound in body fluids and tissues.
📜 SIMILAR VOLUMES
## Abstract An improved synthesis of [1,1′‐^13^C~2~]‐L‐cystine which includes the optical resolution of the labeled N‐acetyl‐S‐benzyl‐DL‐cysteine by __Aspergillus__ acylase into __S__‐benzyl‐L‐cysteine is described.
## Abstract Efficient methods for synthesising L‐[methy‐ ^13^C]methionine from [^13^C]iodomethane and L‐methionine, and L‐[3,4‐^13^C~2~] methionine from [^13^C~2~]ethene, are described; the preparation of [3,3‐^2^H~2~]methionine and [2,3,3‐^2^H~3~]methionine from methionine by an exchange method is
## Abstract D‐Methionine was converted to L‐methionine in a reaction system where four enzymes were used. D‐amino acid oxidase (D‐AAO) from __Arthrobacter protophormiae__ was used for the complete conversion of D‐methionine to 2‐oxo‐4‐methylthiobutyric acid. Catalase was added to prevent 2‐oxo‐4‐me