Synthesis of dipeptide 4-nitroanilides containing non-proteinogenic amino acids
β Scribed by SCHUTKOWSKI, MIKE ;MRESTANI-KLAUS, CARMEN ;NEUBERT, KLAUS
- Book ID
- 115099824
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 788 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0367-8377
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In an effort to increase the probability of finding novel peptides in resin-bound combinatorial libraries displaying affinity to various macromolecular targets, we increased the diversity of a solid-phase library considerably by synthesizing multiple structures on each bead -a motif-library -includi
By treating N-(4-toluenesulfonyl)-N-(tert-butyloxycarbonyl)-dehydroamino acid derivatives with different reactants under different conditions, a variety of new amino acids are obtained, viz. (i) a-alcoxy-a-amino acids, (ii) a,a-diamino acids and (iii) novel b-substituted dehydroamino acids.
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