Synthesis of Dimeric Trifluoromethoxyacridine-derived Pathogen-inactivating Nucleic Acid Intercalators

✍ Scribed by René Csuk; Christian Raschke; Gunnar Göthe; Stefan Reißmann

• Book ID: 101644238
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 256 KB
• Volume: 337
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200400907

✦ Synopsis

Abstract

A series of antiviral active compounds consisting of an intercalating acridine‐derived part, a spacer region and a reactive EDTA‐derived conjugate was synthesized in an easy sequence. Thus, suitably mono‐protected 1, ω‐alkyldiamines gave, upon reaction with 9‐chloro‐2‐trifluoromethoxyacridine, followed by deprotection and reaction with EDTA dianhydride, the target molecules. Incorporation of their Fe(II) complexes in the presence of ascorbate gave a reduction of the phage titer of MS2 phages by several logarithmic decades.