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Synthesis of deuterium-labelled (−)-galanthamine

✍ Scribed by Julien Rouleau; Catherine Guillou

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
107 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of deuterium‐labelled galanthamine is reported. 6‐[^2^H~3~]methoxy‐N‐[^2^H~3~]methyl‐(−)‐galanthamine was obtained in seven steps from galanthamine. The synthesis was carried out by selective O‐ and N‐demethylations. The [^2^H~3~]‐N‐methyl and [^2^H~3~]‐O‐methyl‐groups were introduced by selective aminoreduction and O‐methylation. Copyright © 2008 John Wiley & Sons, Ltd.

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