✦ LIBER ✦

Synthesis of deuterium labelled analogs of the ubiquinone headgroup

✍ Scribed by Henrik Dieks; Klaus Beyer

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 517 KB
Volume: 28
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580280915

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Deuterium labelled analogs of 2,3 ‐ dimethoxy ‐ 5 ‐ methyl ‐ 1,4 ‐ benzoquinone (2,3 ‐ dimethoxy ‐ 5 methyl[^2^H~3~] ‐ 1,4 ‐ benzoquinone; 2,3 ‐ dimethyoxy[^2^H~6~] ‐ 5 ‐ methyl ‐ 1,4 ‐ benzoquinone; 2,3 ‐ dimethoxy[^2^H~6~] ‐ 5 ‐ methyl[^2^H~3~] ‐ 1,4 ‐ benzoquinone) were prepared in five steps starting from 3,4,5 ‐ trihydroxybenzoic acid. The proposed synthetic route results in 100% specific labelling and gives good overall yields. Mass spectra of the labelled derivatives will be briefly discussed.

📜 SIMILAR VOLUMES

Synthesis of 2 deuterium labelled analog

Synthesis of 2 deuterium labelled analogs of veralipride

✍ S. Staveris; A. Schmitt; G. Jamet; R. Kerr R; L. Ottman; L. Jung; J. C. Koffel 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 209 KB

Synthesis of deuterium labelled analogs

Synthesis of deuterium labelled analogs of fluazifop and haloxyfop

✍ Michael J. Bartels; Sterling C. Gatling 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 228 KB

## Abstract Synthetic routes have been described for the preparation of stable isotope‐labelled analogs of two aryloxyphenoxypropionates, each containing approximately four deuterium atoms in the central phenyl ring of the molecule. Fluazifop‐2′,3′,5′,6′‐^2^H~4~ [2‐(4‐((5‐(trifluoromethyl)‐2‐pyridi

Synthesis of deuterium labelled acids

✍ A. J. Kadam; U. V. Desai; R. B. Mane 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 162 KB 👁 1 views

Synthesis of deuterium labelled trifluop

Synthesis of deuterium labelled trifluoperazine

✍ H. U. Shetty; E. M. Hawes; K. K. Midha 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 298 KB

## Abstract Procedures for the preparation of trifluoperazine with two, four and six deuterium atoms are described. Deuterium was introduced in the propylpiperazine side chain by treatment of the appropriate amide with lithium aluminium deuteride. The isotopic purity of the products was greater tha

Synthesis of deuterium-labelled trantint

Synthesis of deuterium-labelled trantinterol

✍ Hongliang Wen; Li Pan; Yingdan Zhang; Jiacheng Ma; Liqiong Qin; Maosheng Cheng 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB

## Abstract Trantinterol, a selective β~2~‐adrenoceptor agonist, is currently in Phase II clinical trials for the treatment of asthma and bronchitis. The synthesis of deuterium‐labelled trantinterol is described. The labelled trantinterol is used as an internal standard for the analysis and metabol

Synthesis of deuterium-labelled etraviri

Synthesis of deuterium-labelled etravirine

✍ Wei Wang; Wenchao Wu; Zucheng Shen; Liqin Chen 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB

## Abstract This study describes the synthesis of deuterium‐labelled etravirine. Etravirine labelled with six deuteriums was prepared in eight steps starting from phenol with excellent chemical purity and isotopic enrichment. It provides important internal standard for the clinical studies of etrav