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Synthesis of deuterium-labeled (24R)-methyl brassinosteroids

✍ Scribed by Vladimir A. Khripach; Vladimir N. Zhabinskii; Olga V. Gulyakevich; Yurii V. Ermolovich; Olga V. Konstantinova

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
199 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Synthesis of labeled brassinosteroids (24‐epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three‐step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24__R__)‐methyl brassinosteroids containing a label in a position which is not subjected to its loss. Copyright © 2011 John Wiley & Sons, Ltd.

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