𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of deuterated and tritiated apogossypol

✍ Scribed by Larry J. Powers; Preston H. Dorsett

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
203 KB
Volume
17
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Apogossypol with deuterium or tritium in the 8 and 8β€² positions can be synthesized by the base catalyzed deformylation of gossypol. The position of the labeling is established by the pmr spectrum of the material derived from the reaction of deuterium oxide and sodium deuteroxide. The specific activity of the tritiated material prepared from tritium oxide and sodium hydroxide is 110m Ci/m Mole. The methods described are also useful for the synthesis and storage of small quantities of unlabeled apogossypol.

πŸ“œ SIMILAR VOLUMES

Synthesis of deuterated and tritiated go
Synthesis of deuterated and tritiated gossypol
✍ Robert D. Stipanovic; Howard J. Williams; David P. Muehleisen; F. W. Plapp Jr. πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 French βš– 126 KB
Synthesis of deuterated and tritiated de
Synthesis of deuterated and tritiated derivatives of enflurane
✍ Terrence R. Burke Jr.; Lance R. Pohl πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 French βš– 296 KB

## Abstract Specifically deuterated derivatives of the inhalation anesthetic enflurane [2‐chloro‐1‐(difluoromethoxy)‐1,1,2‐trifluoroethane] have been synthesized by a facile base catalyzed exchange. Tritiated enflurane has also been synthesized by this procedure.

Synthesis and NMR-analysis of deuterated
Synthesis and NMR-analysis of deuterated and tritiated cyclooctyl acetic acid
✍ Frans M. Kaspersen; Irene H. G. Schlachter; Carel W. Funke; Gerard N. Wagenaars; πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 129 KB

## Abstract To increase the bio‐availability of naturally occurring steroids, esterification of the 17‐hydroxy position is a useful approach. Besides (branched) alkanecarboxylic acids^1^) and cyclohexanecarboxylic acid^2^) also cyclooctyl acetic acid (1) was applied. To establish the biological fat

Antiviral activity of gossypol and apogo
Antiviral activity of gossypol and apogossypol
✍ Preston H. Dorsett; Edwin E. Kerstine; Larry J. Powers πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 300 KB
An investigation into the catalytic deut
An investigation into the catalytic deuteration and tritiation of dehydroproline9-buserelin
✍ J. Oehlke; T. Brankoff; M. Schmidt; M. Brudel; U. Kertscher; H. Berger πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 439 KB

## Abstract For optimizing the catalytic tritiation of peptides, the catalytic deuteration of buserelin and DhP^9^‐buserelin^1^ in DMA after reaction of DhP^9^‐buserelin were comparable in both solvents. The nonspecific incorporation of deuterium found after deuteration of buserelin was clearly low