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Synthesis of cytidyl(3'-5')adenosine bearing 2'(3')-O-leucyl ester via a phosphorothioate triester intermediate

✍ Scribed by Hitoshi Hotoda; Ryuichi Saito; Mitsuo Sekine; Tsujiaki Hata

Book ID: 104204127
Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 733 KB
Volume: 46
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)86683-7

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✦ Synopsis

2'(3')-0-(LeucylICpA was synthesized in the phosphotriester method . The phenylthio group was used as a protecting group of the Internucleotidlc bond. The P-S bond of the trlcster intermedlate was sclectlvely cleaved by using (BuaSnIZO under neutral conditions without cleavage of the leucyl ester bond.

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