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Synthesis of Cyclic Peptides Containing a Thioester Handle for Native Chemical Ligation

✍ Scribed by van de Langemheen, Helmus; Brouwer, Arwin J.; Kemmink, Johan; Kruijtzer, John A. W.; Liskamp, Rob M. J.

Book ID
118019269
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
776 KB
Volume
77
Category
Article
ISSN
0022-3263

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Peptide thioester preparation by Fmoc so
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
✍ Andrew B. Clippingdale; Colin J. Barrow; John D. Wade πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 135 KB πŸ‘ 2 views

Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method