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Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

✍ Scribed by Dheur, Julien; Ollivier, Nathalie; Melnyk, Oleg


Book ID
118273907
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
724 KB
Volume
13
Category
Article
ISSN
1523-7060

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Peptide thioester preparation by Fmoc so
✍ Andrew B. Clippingdale; Colin J. Barrow; John D. Wade πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 135 KB πŸ‘ 2 views

Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method