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On-Resin Native Chemical Ligation for Cyclic Peptide Synthesis 1,2

โœ Scribed by Tulla-Puche, Judit; Barany, George

Book ID
121258214
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
285 KB
Volume
69
Category
Article
ISSN
0022-3263

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Peptide thioester preparation by Fmoc so
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
โœ Andrew B. Clippingdale; Colin J. Barrow; John D. Wade ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 135 KB ๐Ÿ‘ 2 views

Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method