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Direct On-Resin Synthesis of Peptide- α Thiophenylesters for Use in Native Chemical Ligation

✍ Scribed by Bang, Duhee; Pentelute, Brad L.; Gates, Zachary P.; Kent, Stephen B.


Book ID
127153983
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
93 KB
Volume
8
Category
Article
ISSN
1523-7060

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Peptide thioester preparation by Fmoc so
✍ Andrew B. Clippingdale; Colin J. Barrow; John D. Wade 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB 👁 2 views

Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method