Synthesis of cyclic peptide homologs of glutathione as potential antitumor agents
β Scribed by SHEH, LEUNG ;CHEN, BO-LING ;CHEN, CHIA-FU
- Book ID
- 115099061
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 645 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0367-8377
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As a part of our continuing study of colchicinoids as therapeutically useful antitumor drugs, thiocolchicine derivatives, including their phosphate and other water soluble salts, were synthesized and evaluated for inhibition of tubulin polymerization and for in vitro cytotoxicity. Three compounds, 7
i l.bBenroquinones, 1.4-naphthoquinooes, as well as pyridines and quinolincs having 2-alkyloxsziridinyl substituents wcre synthcs i 7 d Thu nicthnd involves formation of aldimines and their oxidation to oxaziridincs. 1.4-Dimethoxyarenes bearing oxuiridinyl suhstiiuents were converted into the corres