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Synthesis of cyclam-capped β-cyclodextrin-bonded silica particles for use as chiral stationary phases in capillary electrochromatography

✍ Scribed by Yinhan Gong; Guoping Xue; Yanqiao Xiang; Jerald S Bradshaw; Milton L Lee; Hian Kee Lee

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
172 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

b-Cyclodextrin (b-CD) was anchored onto silica particles at its C(2) position, derivatized primarily at the C(6) position by treatment with bromoacetyl bromide, and finally reacted with two types of cyclams to form cyclam-capped b-CD-bonded silica particles. When used as chiral stationary phases in capillary electrochromatography, these novel bonded silica particles exhibited excellent enantioselectivities for chiral separations.

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