Application of naphthylcarbamate-substituted β-cyclodextrin bonded silica particles as stationary phase for high-performance liquid chromatography

✍ Scribed by Yinhan Gong; Hian Kee Lee

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 255 KB
• Volume: 26
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/jssc.200390069

✦ Synopsis

Abstract

Naphthylcarbamate‐substituted (3‐(2‐O‐β‐cyclodextrin)‐2‐hydroxypropoxy)‐propylsilyl‐appended silica gel (NSCD‐HPS) has been synthesized via a convenient liquid‐solid phase reaction on a silica gel surface. The chromatographic behavior of NSCD‐HPS in high‐performance liquid chromatography (HPLC) was studied with several disubstituted benzenes and some chiral aromatic compounds under both normal and reversed‐phase conditions. The results show that NSCD‐HPS has excellent selectivity for the separation of positional isomers of disubstituted benzenes and enantiomers of chiral aromatic compounds.