The CI-C9 segment of epothilons was generated by an aldol reaction between chiral aldehyde 3 and ethyl ketone 4. Removal of the TBS protecting groups and debenzylation generated spiro ketal 13 which was analyzed by X-ray crystallography.
✦ LIBER ✦
Synthesis of Cryptothilone 1, the First Cryptophycin—Epothilone Hybrid.
✍ Scribed by James D. White; Helmars Smits; Ernest Hamel
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 20 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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