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Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development.

✍ Scribed by Ulrich Klar; Bernd Buchmann; Wolfgang Schwede; Werner Skuballa; Jens Hoffmann; Rosemarie B. Lichtner

Publisher: John Wiley and Sons
Year: 2007
Weight: 15 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200713212

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Titelbild: Total Synthesis and Antitumor

Titelbild: Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. 47/2006)

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Cover Picture: Total Synthesis and Antit

Cover Picture: Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. Int. Ed. 47/2006)

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**__Nature is a brilliant architect__** for the design of compounds with interesting biological functions. Epothilone B (top), a metabolite of myxobacteria (fruiting body in background), served as the lead structure for the development of an anticancer drug candidate. Optimization efforts led to ZK‐