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Titelbild: Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. 47/2006)

โœ Scribed by Ulrich Klar; Bernd Buchmann; Wolfgang Schwede; Werner Skuballa; Jens Hoffmann; Rosemarie B. Lichtner


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
161 KB
Volume
118
Category
Article
ISSN
0044-8249

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Cover Picture: Total Synthesis and Antit
โœ Ulrich Klar; Bernd Buchmann; Wolfgang Schwede; Werner Skuballa; Jens Hoffmann; R ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 161 KB ๐Ÿ‘ 1 views

**__Nature is a brilliant architect__** for the design of compounds with interesting biological functions. Epothilone B (top), a metabolite of myxobacteria (fruiting body in background), served as the lead structure for the development of an anticancer drug candidate. Optimization efforts led to ZKโ€