We present a four-step A+C route to an optically pure taxoid ABC framework 3a containing suitable functionalities for further elaboration.
Synthesis of coriolin. An approach to a functionalized BC ring system
β Scribed by Schuda, Paul F.; Ammon, Herman L.; Heimann, Martha R.; Bhattacharjee, Sovan
- Book ID
- 126461382
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 978 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Studies directed towards the total synthesis of the diterpene antibiotic, guanacastepene A, of current interest and displaying promising biological activity against drug-resistant pathogens, has led to the acquisition of fully functionalized AB and BC ring segments of the natural product.
## Abstract For Abstract see ChemInform Abstract in Full Text.
A new approach to a highly functionalized 5,7,6-tricyclic core structure of guanacastepene has been developed using the tandem ring-closing metathesis reaction of dienynes as the key step.