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Synthesis of constrained thiorphan analogs as inhibitors of neutral endopeptidase

โœ Scribed by Douglas W. Beight; Shujaath Mehdi; Jack R. Koehl; Gary A. Flynn

Book ID
103983516
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
289 KB
Volume
6
Category
Article
ISSN
0960-894X

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โœ Hideyuki Kanno; Ken Osanai; Tatsuya Nishi; Minoru Iino; Shin-ichi Katakura; Take ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 174 KB

A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.